DiaSorin Explores the Relationship of Growth Hormones and the Adult Skeleton

Nicholas A Tritos, MD, DSc, MMSc, FACP Associate Professor of Medicine, Harvard Medical School

Growth hormone (GH) is secreted by anterior pituitary somatotroph cells in a pulsatile manner throughout life. GH exerts a wide variety of actions in humans, either directly or indirectly by stimulating the synthesis and secretion of insulin-like growth factor 1 (IGF-1). In turn, IGF-1 acts upon both distant tissues and local tissues to mediate several GH actions. In addition, IGF-1 inhibits GH secretion via a negative feedback loop action exerted upon the hypothalamus and pituitary.

In adults, the diagnosis of GH deficiency generally requires GH stimulation…

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